{"id":1043,"date":"2023-11-13T09:19:01","date_gmt":"2023-11-13T01:19:01","guid":{"rendered":"http:\/\/hearthrtllc.com\/?page_id=1043"},"modified":"2025-08-22T14:46:38","modified_gmt":"2025-08-22T06:46:38","slug":"lipoproteins","status":"publish","type":"page","link":"https:\/\/hearthrtllc.com\/en\/lipoproteins\/","title":{"rendered":"Lipoproteins"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"1043\" class=\"elementor elementor-1043\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3dbd2dd elementor-section-height-min-height elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"3dbd2dd\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-9792190\" data-id=\"9792190\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-42ea29d elementor-widget elementor-widget-heading\" data-id=\"42ea29d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Lipoproteins<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-972f667 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"972f667\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8c2c4ec\" data-id=\"8c2c4ec\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-531a23e elementor-toc--minimized-on-tablet elementor-widget elementor-widget-table-of-contents\" data-id=\"531a23e\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;marker_view&quot;:&quot;bullets&quot;,&quot;icon&quot;:{&quot;value&quot;:&quot;fas fa-square-full&quot;,&quot;library&quot;:&quot;fa-solid&quot;},&quot;headings_by_tags&quot;:[&quot;h2&quot;],&quot;no_headings_message&quot;:&quot;No headings were found on this page.&quot;,&quot;minimize_box&quot;:&quot;yes&quot;,&quot;minimized_on&quot;:&quot;tablet&quot;,&quot;hierarchical_view&quot;:&quot;yes&quot;,&quot;min_height&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;min_height_laptop&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;min_height_tablet_extra&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;min_height_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;min_height_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"table-of-contents.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-toc__header\">\n\t\t\t\t\t\t<h3 class=\"elementor-toc__header-title\">\n\t\t\t\t\u76ee\u9304\t\t\t<\/h3>\n\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-toc__toggle-button elementor-toc__toggle-button--expand\" role=\"button\" tabindex=\"0\" aria-controls=\"elementor-toc__531a23e\" aria-expanded=\"true\" aria-label=\"Open table of contents\"><i aria-hidden=\"true\" class=\"fas fa-chevron-down\"><\/i><\/div>\n\t\t\t\t<div class=\"elementor-toc__toggle-button elementor-toc__toggle-button--collapse\" role=\"button\" tabindex=\"0\" aria-controls=\"elementor-toc__531a23e\" aria-expanded=\"true\" aria-label=\"Close table of contents\"><i aria-hidden=\"true\" class=\"fas fa-chevron-up\"><\/i><\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<div id=\"elementor-toc__531a23e\" class=\"elementor-toc__body\">\n\t\t\t<div class=\"elementor-toc__spinner-container\">\n\t\t\t\t<i class=\"elementor-toc__spinner eicon-animation-spin eicon-loading\" aria-hidden=\"true\"><\/i>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-96fff0a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"96fff0a\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-59405ad\" data-id=\"59405ad\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f566dc8 elementor-widget elementor-widget-heading\" data-id=\"f566dc8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u8102\u86cb\u767d\u7684\u7d50\u69cb\u8207\u5206\u985e<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-75bf148 elementor-widget elementor-widget-spacer\" data-id=\"75bf148\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-baf9062 elementor-widget elementor-widget-image\" data-id=\"baf9062\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"3308\" height=\"2556\" src=\"https:\/\/hearthrtllc.com\/wp-content\/uploads\/2023\/11\/Lipoprotein.png\" class=\"attachment-full size-full wp-image-1251\" alt=\"\" srcset=\"https:\/\/hearthrtllc.com\/wp-content\/uploads\/2023\/11\/Lipoprotein.png 3308w, https:\/\/hearthrtllc.com\/wp-content\/uploads\/2023\/11\/Lipoprotein-300x232.png 300w, https:\/\/hearthrtllc.com\/wp-content\/uploads\/2023\/11\/Lipoprotein-768x593.png 768w, https:\/\/hearthrtllc.com\/wp-content\/uploads\/2023\/11\/Lipoprotein-16x12.png 16w\" sizes=\"(max-width: 3308px) 100vw, 3308px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7cfd872 elementor-widget elementor-widget-text-editor\" data-id=\"7cfd872\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\"><span style=\"color: #008080;\">\u25b2 \u5716\u4e00\u3001\u8102\u86cb\u767d\u7684\u7d50\u69cb\u8207\u5206\u985e<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-4be6357\" data-id=\"4be6357\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-be9c00b elementor-widget elementor-widget-spacer\" data-id=\"be9c00b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-885dc8d elementor-widget elementor-widget-text-editor\" data-id=\"885dc8d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u8102\u86cb\u767d (Lipoprotein) \u7684\u7d50\u69cb\u53ef\u4ee5\u5206\u70ba\u5916\u6bbc\u8207\u8102\u8cea\u4e2d\u5fc3\uff0c\u5916\u6bbc\u7531\u78f7\u8102 (Phospholipid) \u8207\u8f09\u8102\u86cb\u767d (Apolipoprotein, Apo) \u6240\u69cb\u6210\uff1b\u8102\u8cea\u4e2d\u5fc3\u5247\u5305\u542b\u81bd\u56fa\u9187 (Cholesterol) \u8207\u4e09\u9178\u7518\u6cb9\u916f (Triglyceride, TG)\u3002\u8102\u86cb\u767d\u6839\u64da\u5bc6\u5ea6\u5927\u5c0f\u53c8\u53ef\u4ee5\u5206\u70ba\u4e73\u7cdc\u5fae\u7c92 (Chylomicron, CM)\u3001\u6975\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d (Very low-density lipoprotein, VLDL)\u3001\u4e2d\u5bc6\u5ea6\u8102\u86cb\u767d (Intermediate-density lipoprotein, IDL)\u3001\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d (Low-density lipoprotein, LDL) \u8207\u9ad8\u5bc6\u5ea6\u8102\u86cb\u767d (High-density lipoprotein, HDL)\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ccb2aba elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ccb2aba\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-9d89de3\" data-id=\"9d89de3\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f1266f3 elementor-widget elementor-widget-heading\" data-id=\"f1266f3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u4f55\u8b02\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\uff08LDL\uff09<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-159820c elementor-widget elementor-widget-spacer\" data-id=\"159820c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-25c54d8 elementor-widget elementor-widget-text-editor\" data-id=\"25c54d8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u8ca0\u8cac\u5c07\u81bd\u56fa\u9187\u7531\u809d\u81df\u904b\u9001\u81f3\u9ad4\u7d30\u80de\u53ca\u7d44\u7e54\u3002\u8a31\u591a\u7814\u7a76\u8868\u660e\u7576\u8840\u6f3f\u4e2d LDL-C \u6fc3\u5ea6\u904e\u9ad8\u6642\uff0c\u5fc3\u8840\u7ba1\u75be\u75c5\u98a8\u96aa\u4ea6\u96a8\u4e4b\u5347\u9ad8\uff0c\u56e0\u6b64 LDL-C \u4e5f\u5e38\u88ab\u53eb\u4f5c\u300c\u58de\u7684\u81bd\u56fa\u9187\u300d\uff0c\u662f\u73fe\u4ee3\u5e38\u7528\u7684\u5fc3\u8840\u7ba1\u75be\u75c5\u98a8\u96aa\u6307\u6a19<span style=\"color: #ff0000;\"><sup>[1]<\/sup><\/span>\u3002\u4f46\u662f\u5728\u4e00\u4e9b\u81e8\u5e8a\u6848\u4f8b\u4e2d\uff0c\u5373\u4fbf\u75c5\u60a3\u9ad4\u6aa2\u5831\u544a\u4e2d LDL-C \u7684\u6fc3\u5ea6\u6b63\u5e38\uff0c\u9084\u662f\u5f97\u5230\u4e86\u52d5\u8108\u7ca5\u72c0\u786c\u5316\u3001\u5fc3\u7d5e\u75db\u7b49\u5fc3\u8840\u7ba1\u76f8\u95dc\u75be\u75c5<sup><span style=\"color: #ff0000;\">[1][2]<\/span><\/sup>\uff0c\u56e0\u6b64 LDL-C \u53ef\u80fd\u4e0d\u662f\u7528\u4f86\u9810\u6e2c\u5fc3\u8840\u7ba1\u75be\u75c5\u98a8\u96aa\u7684\u6700\u7cbe\u78ba\u6a19\u6e96\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-8140264 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8140264\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1950748\" data-id=\"1950748\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-28fea76 elementor-widget elementor-widget-heading\" data-id=\"28fea76\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u964d\u8840\u8102\u85e5\u7269\u7684\u6a5f\u8f49\u539f\u7406<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5221c2c elementor-widget elementor-widget-spacer\" data-id=\"5221c2c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-af42e7a elementor-widget elementor-widget-text-editor\" data-id=\"af42e7a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u76ee\u524d\u91ab\u7642\u4e0a\u91dd\u5c0dLDL-C\u7684\u964d\u8840\u8102\u85e5\u7269\u6709\u5f88\u591a\u7a2e\uff0c\u5176\u4e2d\u6700\u5e38\u898b\u7684\u662f\u300cStatin\u300d\u8207\u300cPCSK9 \u6291\u5236\u5291\u300d\u3002Statin \u6703\u6291\u5236\u81bd\u56fa\u9187\u5728\u809d\u81df\u7684\u5408\u6210\uff1bPCSK9 \u6291\u5236\u5291\u5247\u662f\u85c9\u7531\u8207PCSK9 \u7d50\u5408\u4f86\u63d0\u5347LDL-C\u88ab\u964d\u89e3\u7684\u6548\u7387\u3002<\/p><p>\u00a0<\/p><p>\u5728\u6b63\u5e38\u60c5\u5f62\u4e0b\uff0cLDL-C \u6703\u8207\u809d\u7d30\u80de\u8868\u9762\u7684\u53d7\u9ad4 (Low-density lipoprotein receptor, LDLR) \u7d50\u5408\uff0c\u7136\u5f8c\u7d93\u7531\u80de\u541e\u4f5c\u7528\u88ab\u904b\u9001\u81f3\u809d\u81df\u7d30\u80de\u5167\u5206\u89e3\u3002\u56e0\u6b64\uff0cLDLR \u7684\u6578\u91cf\u8207\u8840\u6db2\u4e2d LDL-C \u6fc3\u5ea6\u6709\u76f4\u63a5\u7684\u95dc\u806f\u6027\uff1aLDLR\u7684\u6578\u91cf\u6108\u591a\uff0cLDL-C\u7684\u6fc3\u5ea6\u5247\u6108\u4f4e\u3002\u800c PCSK9 (Proprotein Convertase Subtilisin\/Kexin type 9) \u662f\u4e00\u7a2e\u4e3b\u8981\u5728\u809d\u81df\u5408\u6210\u7684\u86cb\u767d\u8cea\uff0c\u5b83\u6703\u9078\u64c7\u6027\u7d50\u5408\u81f3 LDLR \u4e0a\uff0c\u4e26\u8b93 LDL-C \u8207 LDLR \u4e00\u540c\u88ab\u5206\u89e3\u3002\u7e3d\u800c\u8a00\u4e4b\uff0c\u82e5\u80fd\u5920\u6709\u6548\u6291\u5236 PCSK9\uff0c\u4fbf\u80fd\u4f7f\u8f03\u5c11\u7684 LDLR \u88ab\u5206\u89e3\u6389\uff0c\u63d0\u9ad8 LDLR \u7684\u56de\u6536\u7387\uff0c\u9032\u800c\u9054\u5230\u63d0\u9ad8 LDL-C \u964d\u89e3\u6548\u7387\u7684\u6548\u679c<span style=\"color: #ff0000;\"><sup>[3]<\/sup><\/span>\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-49b6e4d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"49b6e4d\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d37f353\" data-id=\"d37f353\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-593b6f8 elementor-widget elementor-widget-image\" data-id=\"593b6f8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1024\" height=\"651\" src=\"https:\/\/hearthrtllc.com\/wp-content\/uploads\/2023\/11\/PCSK9_inhibitor.png\" class=\"attachment-large size-large wp-image-1683\" alt=\"\" srcset=\"https:\/\/hearthrtllc.com\/wp-content\/uploads\/2023\/11\/PCSK9_inhibitor.png 5199w, https:\/\/hearthrtllc.com\/wp-content\/uploads\/2023\/11\/PCSK9_inhibitor-300x191.png 300w, https:\/\/hearthrtllc.com\/wp-content\/uploads\/2023\/11\/PCSK9_inhibitor-768x488.png 768w, https:\/\/hearthrtllc.com\/wp-content\/uploads\/2023\/11\/PCSK9_inhibitor-18x12.png 18w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3b5071a elementor-widget elementor-widget-text-editor\" data-id=\"3b5071a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\"><span style=\"color: #008080;\">\u25b2 \u5716\u4e8c\u3001PCSK9 \u8207\u5176\u6291\u5236\u5291\u7684\u4f5c\u7528\u6a5f\u8f49<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4803458 elementor-widget elementor-widget-spacer\" data-id=\"4803458\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-52dca7b elementor-widget elementor-widget-text-editor\" data-id=\"52dca7b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"text-align: justify;\">Alirocumab \u8207 Evolocumab \u5c31\u662fPCSK9 \u7684\u6291\u5236\u5291\uff0c\u81e8\u5e8a\u5be6\u9a57\u7d50\u679c\u8868\u660e\uff0c\u96d6\u7136\u5b83\u5011\u53ef\u4ee5\u964d\u4f4e LDL-C \u6574\u9ad4\u6c34\u5e73\uff0c\u4e26\u4e14\u964d\u4f4e\u5fc3\u8840\u7ba1\u75be\u75c5\u98a8\u96aa\uff0c\u4f46\u662f\u6548\u679c\u537b\u4e0d\u5982\u9810\u671f\uff0c\u5728\u5fc3\u8840\u7ba1\u75be\u75c5\u6b7b\u4ea1\u7387\u4e0a\u4e5f\u4e26\u672a\u9020\u6210\u986f\u8457\u5dee\u7570<\/span><span style=\"text-align: justify; color: #ff0000;\"><span style=\"font-size: 13.5px; line-height: 0; position: relative; vertical-align: baseline; top: -0.5em;\">[4][5]<\/span><\/span><span style=\"text-align: justify;\">\u3002\u9019\u986f\u793a LDL-C \u65cf\u7fa4\u4e2d\uff0c\u4e5f\u8a31\u6709\u4e9b\u985e\u578b\u4e26\u4e0d\u6703\u8207 LDLR \u7d50\u5408\u800c\u88ab\u964d\u89e3\u3002<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f8ae7f0 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f8ae7f0\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-796456a\" data-id=\"796456a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a9f1105 elementor-widget elementor-widget-heading\" data-id=\"a9f1105\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\"><span style=\"font-size: var( --e-global-typography-97ffb18-font-size );font-weight: var( --e-global-typography-97ffb18-font-weight );background-color: var( --e-global-color-astglobalcolor4 )\">\u9670\u96fb\u6027\u6700\u9ad8\u7684\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\uff1aL5<\/span><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-994a1e9 elementor-widget elementor-widget-spacer\" data-id=\"994a1e9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0318326 elementor-widget elementor-widget-image\" data-id=\"0318326\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"3308\" height=\"2556\" src=\"https:\/\/hearthrtllc.com\/wp-content\/uploads\/2023\/11\/L5_Structure.png\" class=\"attachment-full size-full wp-image-1580\" alt=\"\" srcset=\"https:\/\/hearthrtllc.com\/wp-content\/uploads\/2023\/11\/L5_Structure.png 3308w, https:\/\/hearthrtllc.com\/wp-content\/uploads\/2023\/11\/L5_Structure-300x232.png 300w, https:\/\/hearthrtllc.com\/wp-content\/uploads\/2023\/11\/L5_Structure-768x593.png 768w, https:\/\/hearthrtllc.com\/wp-content\/uploads\/2023\/11\/L5_Structure-16x12.png 16w\" sizes=\"(max-width: 3308px) 100vw, 3308px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9ee8c40 elementor-widget elementor-widget-text-editor\" data-id=\"9ee8c40\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\"><span style=\"color: #008080;\">\u25b2 \u5716\u4e09\u3001L5 \u7684\u7d50\u69cb<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-da3d489 elementor-widget elementor-widget-spacer\" data-id=\"da3d489\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ba6e4e4 elementor-widget elementor-widget-image\" data-id=\"ba6e4e4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"3306\" height=\"2556\" src=\"https:\/\/hearthrtllc.com\/wp-content\/uploads\/2023\/12\/LOX-1.png\" class=\"attachment-full size-full wp-image-1749\" alt=\"\" srcset=\"https:\/\/hearthrtllc.com\/wp-content\/uploads\/2023\/12\/LOX-1.png 3306w, https:\/\/hearthrtllc.com\/wp-content\/uploads\/2023\/12\/LOX-1-300x232.png 300w, https:\/\/hearthrtllc.com\/wp-content\/uploads\/2023\/12\/LOX-1-768x594.png 768w, https:\/\/hearthrtllc.com\/wp-content\/uploads\/2023\/12\/LOX-1-16x12.png 16w\" sizes=\"(max-width: 3306px) 100vw, 3306px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ae5fc94 elementor-widget elementor-widget-text-editor\" data-id=\"ae5fc94\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\"><span style=\"color: #008080;\">\u25b2 \u5716\u56db\u3001L1 \u8207 L5 \u7684\u53d7\u9ad4\u5206\u5225\u70ba LDLR \u8207 LOX-1<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-386cf4c elementor-widget elementor-widget-spacer\" data-id=\"386cf4c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-3ab64d4\" data-id=\"3ab64d4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-112bdb6 elementor-widget elementor-widget-spacer\" data-id=\"112bdb6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4e1d36c elementor-widget elementor-widget-text-editor\" data-id=\"4e1d36c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u9670\u96fb\u6027\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d (Electronegative low-density lipoprotein) \u7684\u6982\u5ff5\u9996\u6b21\u5728 1979 \u5e74\u7531\u4efb\u8077\u65bc\u8c9d\u52d2\u91ab\u5b78\u9662 (Baylor College of Medicine) \u7684 Gotto \u6559\u6388\u7b49\u4eba\u63d0\u51fa<span style=\"color: #ff0000;\"><sup>[6]<\/sup><\/span>\uff0c\u800c\u5f8c\u53e6\u4e00\u7bc7 1988 \u5e74\u7684\u8ad6\u6587\u4ea6\u8b49\u5be6\u5176\u5b58\u5728<span style=\"color: #ff0000;\"><sup>[7]<\/sup><\/span>\u3002\u897f\u5143 2003 \u5e74\uff0c\u9673\u73e0\u749c\u6559\u6388\uff08\u672c\u516c\u53f8\u5275\u8fa6\u4eba\uff09\u65bc\u671f\u520a <em>Circulation<\/em> \u4e2d\u767c\u8868\u4e86\u4e00\u7bc7\u8ad6\u6587\uff0c\u4ed6\u6839\u64da\u9670\u96fb\u6027\u7684\u5f37\u5f31\u53c8\u5c07 LDL \u5206\u70ba\u4e94\u500b\u4e9e\u578b\uff1aL1\u3001L2\u3001L3\u3001L4 \u8207 L5\uff0c\u5176\u4e2d L1\u662f\u6b63\u5e38\u7684 LDL\uff1bL5 \u7684\u9670\u96fb\u6027\u6700\u9ad8\u3001\u4e5f\u6700\u5bb9\u6613\u88ab\u6c27\u5316\uff0c\u4e5f\u662f\u9020\u6210\u52d5\u8108\u7ca5\u72c0\u786c\u5316\u7b49\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u4e3b\u8981\u539f\u56e0<span style=\"color: #ff0000;\"><sup>[2][8][9]<\/sup><\/span>\u3002<\/p><p><br><\/p>\n<p><\/p>\n<p style=\"font-size: 18px; font-style: normal; font-weight: 400;\">\u5f9e\u7d50\u69cb\u4e0a\u4f86\u770b\uff0cL1 \uff08\u5373\u6b63\u5e38LDL\uff09\u7684\u8f09\u8102\u86cb\u767d B100 (Apolipoprotein B100, ApoB-100) \u7d04\u5360\u7e3d\u6bd4\u4f8b 99.71%\uff1b\u800c L5 \u7684\u8f09\u8102\u86cb\u767d B100 \u50c5\u4f54 61.26%\uff0c\u5176\u9918\u90e8\u5206\u7531\u8f09\u8102\u86cb\u767d a (Apolipoprotein a, Apo(a))\u3001\u8f09\u8102\u86cb\u767d A1 (Apolipoprotein A1, ApoA1)\u3001\u8f09\u8102\u86cb\u767d C3 (Apolipoprotein C3, ApoCIII) \u53ca\u8f09\u8102\u86cb\u767d E (Apoliprotein E) \u6240\u69cb\u6210\uff0c\u56e0\u6b64\u4e5f\u651c\u5e36\u4e86\u66f4\u591a\u7684\u8ca0\u96fb\u8377<span style=\"color: #ff0000;\"><sup>[9]<\/sup><\/span>\u3002<\/p><p style=\"font-size: 18px; font-style: normal; font-weight: 400;\"><br><\/p>\n<p style=\"font-size: 18px; font-style: normal; font-weight: 400;\">\n<\/p><p style=\"font-size: 18px; font-style: normal; font-weight: 400;\">\n<\/p><p style=\"font-size: 18px; font-style: normal; font-weight: 400;\"><span style=\"background-color: var( --e-global-color-astglobalcolor4 ); text-align: start;\">\u5728 L1 \u8207 LDLR \u7d50\u5408\u7684\u904e\u7a0b\u4e2d\uff0cApoB-100 \u4e0a\u5e36\u6b63\u96fb\u8377\u7684 \u03b5-\u80fa\u57fa (NH<\/span><span style=\"background-color: var( --e-global-color-astglobalcolor4 ); font-size: 13.5px; line-height: 0; position: relative; vertical-align: baseline; top: -0.5em; text-align: start;\">3+<\/span><span style=\"background-color: var( --e-global-color-astglobalcolor4 ); text-align: start;\">) \u626e\u6f14\u8457\u975e\u5e38\u91cd\u8981\u7684\u89d2\u8272\u3002L1 \u6703\u900f\u904e\u9019\u500b\u80fa\u57fa\u8207 LDLR \u4e0a\u5e36\u8ca0\u96fb\u7684\u6b98\u8de1\u76f8\u4e92\u4f5c\u7528\uff0c\u800c\u5f8c\u7d93\u7531\u80de\u541e\u4f5c\u7528\u9032\u5165\u7d30\u80de\u5167\u88ab\u5206\u89e3\u3002\u800c L5 \u56e0\u70ba\u651c\u5e36\u8f03\u591a\u7684\u8ca0\u96fb\u8377\uff0c\u5728\u69cb\u578b\u4e0a\u548c LDLR \u7684\u89aa\u548c\u529b\u5f88\u4f4e\uff0c\u56e0\u6b64\u4e0d\u6703\u88ab LDLR \u6240\u8fa8\u8b58<\/span><span style=\"background-color: var( --e-global-color-astglobalcolor4 ); text-align: start; color: #ff0000;\"><span style=\"font-size: 13.5px; line-height: 0; position: relative; vertical-align: baseline; top: -0.5em;\">[9]<\/span><\/span><span style=\"background-color: var( --e-global-color-astglobalcolor4 ); text-align: start;\">\u3002\u8207 L1 \u4e0d\u540c\u7684\u662f\uff0cL5 \u6703\u548c\u7d30\u80de\u8868\u9762\u7684 LOX-1 (Lectin-like oxLDL receptor) \u53d7\u9ad4\u7d50\u5408\uff0c\u9032\u800c\u555f\u52d5\u4e0b\u6e38\u7684\u8a0a\u606f\u50b3\u905e\u8def\u5f91\uff0c\u9020\u6210\u7d30\u80de\u51cb\u4ea1\u3002\u800c\u904e\u591a\u7684\u6b7b\u7d30\u80de\u5806\u7a4d\u65bc\u8840\u7ba1\u5167\u58c1\uff0c\u9020\u6210\u8840\u7ba1\u7ba1\u5f91\u7e2e\u5c0f\uff0c\u4fbf\u662f\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u4f86\u6e90\u4e4b\u4e00\u3002<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9b2f48b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9b2f48b\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d345c22\" data-id=\"d345c22\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-adfeedc elementor-widget elementor-widget-heading\" data-id=\"adfeedc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u4f55\u8b02\u9ad8\u5bc6\u5ea6\u8102\u86cb\u767d\uff08HDL\uff09<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-46309c7 elementor-widget elementor-widget-spacer\" data-id=\"46309c7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-46490b5 elementor-widget elementor-widget-text-editor\" data-id=\"46490b5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u9ad8\u5bc6\u5ea6\u8102\u86cb\u767d\u662f\u8102\u86cb\u767d\u7684\u4e00\u7a2e\uff0c\u8ca0\u8cac\u5c07\u8840\u6db2\u4e2d\u7684\u81bd\u56fa\u9187\u904b\u9001\u56de\u809d\u81df\u3002\u8a31\u591a\u6d41\u6027\u75c5\u5b78\u7684\u7814\u7a76\u4e2d\u986f\u793a\uff0cHDL-C \u8207\u5fc3\u8840\u7ba1\u75be\u75c5\u9593\u5177\u6709\u986f\u8457\u7684\u8ca0\u76f8\u95dc\u95dc\u806f\u6027\u3002\u56e0\u6b64\uff0cHDL-C \u53c8\u5e38\u88ab\u7a31\u4f5c\u300c\u597d\u7684\u81bd\u56fa\u9187\u300d\uff0c\u4e26\u4e14\u6210\u70ba\u73fe\u4ee3\u5e38\u898b\u7684\u8840\u8102\u80aa\u6aa2\u6e2c\u9805\u76ee\uff0c\u662f\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u8861\u91cf\u6307\u6a19\u4e4b\u4e00\u3002\u7136\u800c\uff0c\u8fd1\u5e74\u4f86\u6709\u6108\u4f86\u6108\u591a\u7684\u7814\u7a76\u7d50\u679c\u8868\u660e\uff0cHL-C \u4e26\u975e\u9810\u9632\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u53ef\u9760\u4f9d\u64da<span style=\"color: #ff0000;\"><sup>[10][11][12][13][14]<\/sup><\/span>\u3002\u00a0\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-b546d1a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"b546d1a\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-46d7bba\" data-id=\"46d7bba\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2635f7a elementor-widget elementor-widget-heading\" data-id=\"2635f7a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u81bd\u56fa\u9187\u916f\u8f49\u79fb\u86cb\u767d\uff08CETP\uff09<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5817f27 elementor-widget elementor-widget-spacer\" data-id=\"5817f27\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bab2823 elementor-widget elementor-widget-text-editor\" data-id=\"bab2823\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"font-size: 18px; font-style: normal; font-weight: 400;\">\u81bd\u56fa\u9187\u916f\u8f49\u79fb\u86cb\u767d (Cholesteryl ester transfer protein, CETP) \u662f\u81bd\u56fa\u9187\u4ee3\u8b1d\u8def\u5f91\u4e2d\u7684\u4e00\u7a2e\u86cb\u767d\u8cea\uff0c\u5b83\u7684\u529f\u80fd\u662f\u5c07 HDL \u4e2d\u7684\u81bd\u56fa\u9187\u8102 (Cholesteryl ester, CE) \u8f49\u79fb\u81f3\u6975\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d (Very low density lipoprotein, VLDL) \u8207 LDL\uff0c\u4e26\u5c07 VLDL \u8207 LDL \u6240\u651c\u5e36\u7684\u4e09\u9178\u7518\u6cb9\u916f\u50b3\u9001\u81f3 HDL \u4e2d<span style=\"color: #ff0000;\"><sup>[10][12]<\/sup><\/span>\u3002\u56e0\u6b64\u82e5\u80fd\u6709\u6548\u6291\u5236 CETP\uff0c\u5c31\u80fd\u63d0\u5347\u8840\u6db2\u4e2d\u300c\u597d\u7684\u81bd\u56fa\u9187\u300d\u6fc3\u5ea6\u3002<\/p><p>\u79d1\u5b78\u5bb6\u4fbf\u4ee5Torcetrapib<span style=\"color: #ff0000;\"><sup>[10]<\/sup><\/span>\u3001Dalcetrapib<span style=\"color: #ff0000;\"><sup>[11]<\/sup><\/span> \u8207 Evacetrapib<span style=\"color: #ff0000;\"><sup>[13]<\/sup> <\/span>\u4e09\u7a2e\u85e5\u7269\u4f86\u6291\u5236 CETP\uff1a\u4ed6\u5011\u5206\u5225\u7d66\u4e88\u60a3\u6709\u6025\u6027\u51a0\u72c0\u52d5\u8108\u7d9c\u5408\u75c7\uff0c\u4ee5\u53ca\u5177\u6709\u9ad8\u5fc3\u8840\u7ba1\u75be\u75c5\u98a8\u96aa\u7684\u8a66\u9a57\u8005\u670d\u7528\u4e0a\u8ff0\u4e09\u7a2e\u85e5\u7269\u3002\u5be6\u9a57\u7d50\u679c\u986f\u793a\uff0c\u96d6\u7136 HDL \u7684\u6fc3\u5ea6\u7686\u5f97\u5230\u4e86\u986f\u8457\u7684\u63d0\u5347\uff0c\u4f46\u60a3\u8005\u7684\u5fc3\u8840\u7ba1\u75be\u75c5\u98a8\u96aa\u4e26\u6c92\u6709\u56e0\u70ba HDL \u7684\u6fc3\u5ea6\u5347\u9ad8\u800c\u964d\u4f4e<span style=\"color: #ff0000;\"><sup>[10][11][13]<\/sup><\/span>\u3002Furtado and Sacks et al. <em>ATVB<\/em> (2022) \u7684\u5be6\u9a57\u5247\u767c\u73fe\uff0cCETP \u6291\u5236\u5291 Torcetrapib \u8207 Evacetrapib \u6703\u589e\u52a0\u8f09\u8102\u86cb\u767d A1 (Apolipoprotein A1, ApoA-I) \u7684\u6fc3\u5ea6\uff0c\u7279\u5225\u662f\u90a3\u4e9b\u7d50\u69cb\u4e2d\u542b\u6709\u8f09\u8102\u86cb\u767d C-III (Apolipoprotein C3, ApoC-III) \u7684 HDL \u4e9e\u578b\uff0c\u9032\u800c\u63d0\u9ad8\u5fc3\u8840\u7ba1\u75be\u75c5\u98a8\u96aa<span style=\"color: #ff0000;\"><sup>[14]<\/sup><\/span>\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-0cd0a7d\" data-id=\"0cd0a7d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-afbf843 elementor-widget elementor-widget-spacer\" data-id=\"afbf843\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b1445f5 elementor-widget elementor-widget-image\" data-id=\"b1445f5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"3807\" height=\"2941\" src=\"https:\/\/hearthrtllc.com\/wp-content\/uploads\/2023\/11\/CETP_finction.png\" class=\"attachment-full size-full wp-image-1581\" alt=\"\" srcset=\"https:\/\/hearthrtllc.com\/wp-content\/uploads\/2023\/11\/CETP_finction.png 3807w, https:\/\/hearthrtllc.com\/wp-content\/uploads\/2023\/11\/CETP_finction-300x232.png 300w, https:\/\/hearthrtllc.com\/wp-content\/uploads\/2023\/11\/CETP_finction-768x593.png 768w, https:\/\/hearthrtllc.com\/wp-content\/uploads\/2023\/11\/CETP_finction-16x12.png 16w\" sizes=\"(max-width: 3807px) 100vw, 3807px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2f8be12 elementor-widget elementor-widget-text-editor\" data-id=\"2f8be12\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\"><span style=\"color: #008080;\">\u25b2 \u5716\u4e94\u3001CETP \u7684\u4f5c\u7528\u6a5f\u8f49<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-cae7fd1 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"cae7fd1\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c573113\" data-id=\"c573113\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-712bbaf elementor-widget elementor-widget-heading\" data-id=\"712bbaf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u9670\u96fb\u6027\u6700\u9ad8\u7684\u9ad8\u5bc6\u5ea6\u8102\u86cb\u767d\uff1aH5<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-766c7b8 elementor-widget elementor-widget-spacer\" data-id=\"766c7b8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c22e858 elementor-widget elementor-widget-text-editor\" data-id=\"c22e858\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>HDL \u53ef\u4ee5\u4f9d\u64da\u6240\u5e36\u96fb\u8377\u7684\u591a\u5be1\u5206\u6210\u4e94\u500b\u4e9e\u578b\uff0c\u5206\u5225\u662f H1~H5\uff0c\u5176\u4e2dH5\u662f\u9670\u96fb\u6027\u6700\u9ad8\u7684\u4e9e\u578b\uff0c\u800cApoC-III\u4e3b\u8981\u8868\u73fe\u5728 H5 \u4e4b\u4e0a<span style=\"color: #ff0000;\"><sup>[14][15]<\/sup><\/span>\u3002\u53e6\u5916\uff0c\u76f8\u95dc\u7814\u7a76\u6307\u51fa\uff0cApoC-III \u662f HDL \u529f\u80fd\u5931\u8861\u7684\u6307\u6a19\u4e4b\u4e00<span style=\"color: #ff0000;\"><sup>[12]<\/sup><\/span>\u3002\u56e0\u6b64\u82e5\u80fd\u7cbe\u78ba\u6e2c\u91cf\u51fa\u8840\u6f3f\u4e2d\u7684 H5 \u6fc3\u5ea6\uff0c\u5c07\u6703\u662f\u6bd4\u6e2c\u91cf HDL-C \u66f4\u6709\u6548\u7684\u5fc3\u8840\u7ba1\u75be\u75c5\u98a8\u96aa\u8a55\u65b7\u6a19\u6e96\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-977afe4 elementor-widget elementor-widget-spacer\" data-id=\"977afe4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e3beb6c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e3beb6c\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5701898\" data-id=\"5701898\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ac1ad03 elementor-widget elementor-widget-heading\" data-id=\"ac1ad03\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u4f55\u8b02\u6975\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\uff08VLDL\uff09<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6d3a112 elementor-widget elementor-widget-spacer\" data-id=\"6d3a112\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-dcd4c63 elementor-widget elementor-widget-text-editor\" data-id=\"dcd4c63\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u6975\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\uff08VLDL\uff09\u662f\u4e00\u7a2e\u7531\u809d\u81df\u5408\u6210\u7684\u8102\u86cb\u767d\uff0c\u4e3b\u8981\u529f\u80fd\u662f\u5c07\u4e09\u9178\u7518\u6cb9\u8102\uff08Triglycerides, TG\uff09\u5f9e\u809d\u81df\u904b\u9001\u81f3\u5176\u4ed6\u7d44\u7e54\u4f86\u7522\u751f\u6216\u5132\u5b58\u80fd\u91cf\uff08\u5982\u808c\u8089\u7d44\u7e54\u53ca\u8102\u80aa\u7d44\u7e54\uff09\u3002VLDL\u7d93\u7531\u4e00\u9023\u4e32\u9175\u7d20\u4f5c\u7528\u8207\u8102\u8cea\u8f49\u63db\u904e\u7a0b\uff0c\u6703\u5728\u8840\u6db2\u4e2d\u9010\u6b65\u4ee3\u8b1d\u70ba IDL\uff08\u4e2d\u5bc6\u5ea6\u8102\u86cb\u767d\uff09\uff0c\u6700\u5f8c\u5f62\u6210 LDL\uff08\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\uff09\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8f15707 elementor-widget elementor-widget-spacer\" data-id=\"8f15707\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e01200b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e01200b\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1497bb8\" data-id=\"1497bb8\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ca04967 elementor-widget elementor-widget-heading\" data-id=\"ca04967\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u9670\u96fb\u6027\u6700\u9ad8\u7684\u6975\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d: V5<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7dc07f4 elementor-widget elementor-widget-spacer\" data-id=\"7dc07f4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-94b2664 elementor-widget elementor-widget-text-editor\" data-id=\"94b2664\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>VLDL-C\u6703\u5728\u9ad4\u5167\u9032\u4e00\u6b65\u4ee3\u8b1d\u6210 LDL-C\uff0c\u56e0\u6b64\uff0cV5\u53ef\u80fd\u70baL5\u7684\u524d\u8eab\u3002\u5728\u52d5\u7269\u5be6\u9a57\u4e2d\uff0c\u9ad8V5% \u5df2\u88ab\u767c\u73fe\u6703\u5c0e\u81f4\u5c0f\u9f20\u5fc3\u81df\u529f\u80fd\u8fc5\u901f\u53d7\u640d\uff0c\u751a\u81f3\u5f15\u767c\u5fc3\u808c\u6897\u585e<span style=\"color: #ff0000;\"><sup>[16]<\/sup><\/span>\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6a3aaf0 elementor-widget elementor-widget-spacer\" data-id=\"6a3aaf0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-8c5f437 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8c5f437\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-48a41d8\" data-id=\"48a41d8\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f9886e8 elementor-widget elementor-widget-spacer\" data-id=\"f9886e8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-892a168 elementor-widget elementor-widget-heading\" data-id=\"892a168\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u53c3\u8003\u6587\u737b<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-77c3d34 elementor-widget elementor-widget-spacer\" data-id=\"77c3d34\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1efbcbb elementor-widget elementor-widget-text-editor\" data-id=\"1efbcbb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #ff0000;\">[1]<\/span> Ke, L. Y., Stancel, N., Bair, H., <strong>Chen, C. H.<\/strong> 2014. The Underlying Chemistry of Electronegative LDL\u2019s Atherogenicity. <em>Curr Atheroscler Rep. <\/em>16:428.<\/p><p><span style=\"color: #ff0000;\">[2]\u00a0<\/span>Wang, G. J., Chang, C. T., Yang, C. H., <strong>Chen, C. H.<\/strong> 2012. Negatively charged L5 as a naturally occurring atherogenic low-density lipoprotein. <em>BioMedicine<\/em>. 2(4):147-154.<\/p><p><span style=\"color: #ff0000;\">[3]<\/span> Shimada, Y. J., Cannon, C. P. PCSK9 (Proprotein convertase subtilisin\/kexin type 9) inhibitors: past, present, and the future. <em>European Heart Journal<\/em>, 36(36):2415\u20132424.<\/p><p><span style=\"color: #ff0000;\">[4]<\/span> Karatasakis, A., Danek, B. A., Karacsonyi, J., Rangan, B. V., Roesle, M. K., Knickelbine, T., Miedema, M. D., Khalili, H., Ahmad, Z., Abdullah, S., Banerjee, S., Brilakis, E. S. 2017. Effect of PCSK9 Inhibitors on Clinical Outcomes in Patients With Hypercholesterolemia: A Meta\u2010Analysis of 35 Randomized Controlled Trials. <em>J Am Heart Assoc<\/em>. 9;6(12):e006910.<\/p><p><span style=\"color: #ff0000;\">[5]<\/span> Navarese, E. P., Robinson, J. G., Kowalewski, M., Kolodziejczak, M., Andreotti, F., Bliden, K., Tantry, U., Kubica, J., Raggi, P., Gurbel, P. A. 2018. Association Between Baseline LDL-C Level and Total and Cardiovascular Mortality After LDL-C Lowering: A Systematic Review and Meta-analysis. <em>JAMA<\/em>. 319(15):1566-1579.<\/p><p><span style=\"color: #ff0000;\">[6]<\/span> Hoff, H. F., Bradley, W. A., Heideman, C. L., Gaubatz, J. W., Karagas, M. D., Gotto Jr, A. M. 1979. Characterization of low density lipoprotein-like particle in the human aorta from grossly normal and atherosclerotic regions. <em>Biochim Biophys Acta<\/em>. 573(2):0\u2013374.<\/p><p><span style=\"color: #ff0000;\">[7]<\/span> Avogaro, P., Bon, G. B., Cazzolato, G. 1988. Presence of a modified low density lipoprotein in humans. <em>Arteriosclerosis<\/em>. 8(1):79-87.<\/p><p><span style=\"color: #ff0000;\">[8]<\/span> <strong>Chen, C. H.<\/strong>, Jiang, T., Yang, J. H., Jiang, W., Lu, J., Marathe, G. K., Pownall, H. J., Ballantyne, C. M., McIntyre, T. M., Henry, P. D., Yang, C. H. 2003. Low-Density Lipoprotein in Hypercholesterolemic Human Plasma Induces Vascular Endothelial Cell Apoptosis by Inhibiting Fibroblast Growth Factor 2 Transcription. Circulation. 107:2102\u20132108.<\/p><p><span style=\"color: #ff0000;\">[9] <\/span>Ke, L. Y., Engler, D. A., Lu, J., Matsunami, R. K., Chan, H. C., Wang, G. H., Yang, C. H., Chang, J. H., <strong>Chen, C.H.<\/strong> 2011. Chemical composition\u2013oriented receptor selectivity of L5, a naturally occurring atherogenic low-density lipoprotein. Pure Appl Chem. 83(9):10.<\/p><p><span style=\"color: #ff0000;\">[10]<\/span> Barter, P. J., Caulfield, M., Eriksson, M., Grundy, S. M., Kastelein, J. J., Komajda, M., Lopez-Sendon, J., Mosca, L., Tardif, J. C., Waters, D. D., Shear, C. L., Revkin, J. H., Buhr, K. A., Fisher, M. R., Tall, A. R., Brewer, B. 2007. Effects of Torcetrapib in Patients at High Risk for Coronary Events. <em>N Engl J Med<\/em>. 22;357(21):2109-22.<\/p><p><span style=\"color: #ff0000;\">[11]<\/span> Schwartz, G. G., Olsson, A. G., Abt, M., Ballantyne, C. M., Barter, P. J., Brumm, J., Chaitman, B.R., Holme, I. M., Kallend, D., Leiter, L. A., Leitersdorf, E., McMurray, J. J. V., Mundl, H., Nicholls, S. J., Shah, P. K., Tardif, J. C., Wright, R. S. 2012. Effects of Dalcetrapib in Patients with a Recent Acute Coronary Syndrome.<em> N Engl J Med<\/em>. 367:2089-2099.<\/p><p><span style=\"color: #ff0000;\">[12]<\/span> Zheng, C., Aikawa, M. 2012. High-Density Lipoproteins: From Function to Therapy. <em>Journal of the American College of Cardiology (JACC)<\/em>. 60(23): 2380-2383.<\/p><p><span style=\"color: #ff0000;\">[13]<\/span> Lincoff, A. M., Nicholls, S. J., Riesmeyer, J. S., Barter, P. J., Brewer, H. B., Fox, K. A. A., Gibson, C. M., Granger, C., Menon, V., Montalescot, G., Rader, D., Tall, A. R., McErlean, E., Wolski, K., Ruotolo, G., Vangerow, B., Weerakkody, G., Goodman, S. G., Conde, D., McGuire, D. K., Nicolau, J. C., Leiva-Pons, J. L., Pesant, Y., Li, W., Kandath, D., Kouz, S., Tahirkheli, N., Mason, D., Nissen, S. E. 2017. Evacetrapib and Cardiovascular Outcomes in High-Risk Vascular Disease. <em>N Engl J Med<\/em>. 18;376(20):1933-1942.<\/p><p><span style=\"color: #ff0000;\">[14]<\/span> Furtado, J. D., Ruotolo, G., Nicholls, S. J., Dullea, R., Carvajal-Gonzalez, S., Sacks, F. M. 2022. Pharmacological Inhibition of CETP (Cholesteryl Ester Transfer Protein) Increases HDL (HighDensity Lipoprotein) That Contains ApoC3 and Other HDL Subspecies Associated with Higher Risk of Coronary Heart Disease. <em>Arterioscler Thromb Vasc Biol<\/em>. 42:227\u2013237.<\/p><p><span style=\"color: #ff0000;\">[15]<\/span> Hsieh, J. Y., Chang, C. T., Huang, M. T., Chang, C. M., Chen, C. Y., Shen, M. Y., Liao, H. Y., Wang, G. J., <strong>Chen, C. H.<\/strong>, Chen, C. J., Yang, C. Y. 2013. Biochemical and Functional Characterization of Charge-Defined Subfractions of High-Density Lipoprotein from Normal Adults. <em>Analytical Chemistry<\/em>. 85(23):11440\u201311448.<\/p><p><span style=\"color: #ff0000;\">[16]<\/span> Lee, H. C., Chen, C. C., Tsai, W. C., Lin, H. T., Shiao, Y. L., Sheu, S. H., Wu, B. N., <strong>Chen, C. H.<\/strong>, &amp; Lai, W. T. 2017. Very-Low-Density Lipoprotein of Metabolic Syndrome Modulates Gap Junctions and Slows Cardiac Conduction.\u00a0<em>Scientific reports<\/em>,\u00a0<em>7<\/em>(1), 12050.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b089591 elementor-widget elementor-widget-spacer\" data-id=\"b089591\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Lipoproteins \u76ee\u9304 \u8102\u86cb\u767d\u7684\u7d50\u69cb\u8207\u5206\u985e \u25b2 \u5716\u4e00\u3001\u8102\u86cb\u767d\u7684\u7d50\u69cb\u8207\u5206\u985e \u8102\u86cb\u767d (Lipoprote [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"full-width-container","site-content-style":"unboxed","site-sidebar-style":"unboxed","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":"","_wp_rev_ctl_limit":""},"class_list":["post-1043","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/hearthrtllc.com\/en\/wp-json\/wp\/v2\/pages\/1043","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hearthrtllc.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/hearthrtllc.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/hearthrtllc.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hearthrtllc.com\/en\/wp-json\/wp\/v2\/comments?post=1043"}],"version-history":[{"count":31,"href":"https:\/\/hearthrtllc.com\/en\/wp-json\/wp\/v2\/pages\/1043\/revisions"}],"predecessor-version":[{"id":4793,"href":"https:\/\/hearthrtllc.com\/en\/wp-json\/wp\/v2\/pages\/1043\/revisions\/4793"}],"wp:attachment":[{"href":"https:\/\/hearthrtllc.com\/en\/wp-json\/wp\/v2\/media?parent=1043"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}